Inter will look to Marcus Thuram and Marko Arnautovic in a Serie A game against Frosinone who are desperate for points in the race for survival.
It kicks off at 19:45 UK time (GMT+1) at the Stadio Stirpe in Frosinone.
The hosts are still involved in the race for survival being just two points above 18th-placed Udinese in the Serie A table.
Several players are not available, including regular starters Simone Romagnoli and Stefano Turati who are injured and the suspended Enzo Barrenechea.
Francesco Acerbi is the only unavailable player for Inter as the Italy international is still recovering from groin problems.
The Nerazzurri have already been crowned Serie A champions, so Simone Inzaghi is expected to rotate, leaving Hakan Calhanoglu, Alessandro Bastoni, Henrikh Mkhitaryan and Lautaro Martinez on the bench.
Arnautovic and Thuram will start in attack, Yann Sommer will return between the sticks, while Nicolò Barella and Davide Frattesi are expected to start in central midfield alongside Kristjan Asllani.
Frosinone vs Inter – probable line-ups
Frosinone (3-4-2-1): Cerofolini; Lirola, Okoli, Bonifazi; Zortea, Brescianini, Mazzitelli, Reinier, Valeri; Soulé, Cheddira.
Inter (3-5-2): Sommer; Bisseck, de Vrij, Carlos Augusto; Darmian, Frattesi, Asllani, Barella, Dimarco; Thuram, Arnautovic.